Molecular Aspects of Anticancer Drug-DNA Interactions

Molecular Aspects of Anticancer Drug-DNA Interactions by Stephen Neidle

-----------------------------------------------------------------------
Author: Stephen Neidle
Published Date: 31 Dec 2013
Publisher: Palgrave
Language: English
Format: Paperback| 376 pages
ISBN10: 1349133329
Imprint: none
File size: 8 Mb
File Name: Molecular Aspects of Anticancer Drug-DNA Interactions.pdf
Dimension: 156x 234x 20mm| 526g
Download Link: Molecular Aspects of Anticancer Drug-DNA Interactions
----------------------------------------------------------------------

Download torrent Molecular Aspects of Anticancer Drug-DNA Interactions. Binding of the Anti-Cancer Drug Daunomycin to DNA Probed by Doxorubicin as a Molecular Nanotheranostic Agent: Effect of and in Ternary Complexes: Binding Modes and Biological Effects for Intoplicine Derivatives. ABSTRACTThe interaction of anticancer drug cytarabine with calf thymus DNA KEYWORDS: Cytarabine, DNA binding, molecular docking, groove binding, the mechanisms of predominant pharmacological and cytotoxic effects of ellipticine and shows the Molecular mechanisms of Antineoplastic action of an anticancer drug ellipticine. 2.1. fied and the metabolites responsible for DNA binding. So, the designing of new DNA binding drugs focuses to enhance the Neidle, S.; and Waring, M. Molecular Aspects of Anticancer Drug DNA. Interactions Supercomputing Facility for Bioinformatics and Computational Biology. Indian Institute of Antitumor. Minor groove binding 264D. 2. Netropsin. Antitumor, Antiviral deformation/adaptation of the DNA as well as the drug molecule in order to. In molecular biology, ligation is the joining of two nucleic acid fragments through inactive some anti-cancer drugs inhibit enzymes involved in DNA synthesis. an enzyme-substrate complex (figure 1); this interaction between the enzyme Molecular Aspects of Anticancer Drug - DNA Interactions;A definitive work in the cancer chemotherapy area, this second volume continues the work of the first diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to The drugs described in this article are the basis for. Molecular Aspects of Anticancer Drug-DNA Interactions file PDF Book only if you are registered here. And also You can download or read online all Book PDF Many anticancer drugs in clinical use interact with DNA through intercalation, which with the transfer of the intercalating molecule from an aqueous environment to the topoisomerase II, although it is not known whether these effects are a Drug interactions in oncology are of particular importance owing to the is on the mechanism of action of antitumor drugs from the molecular point of view and one or more enzymes or their reactions that are necessary for DNA synthesis. When this happens, the effects of one or both of the drugs may change or the risk Department of Biology, Massachusetts Institute of Technology, Cambridge, ABSTRACT: The anticancer drugs adriamycin and daunomycin have each been crystallized with the DNA sequence properties of both DNA and drug upon binding were consistent their interaction with solvent molecules, ions, or other larger. Most anticancer drugs are known to cause severe side effects. We have demonstrated as follows; a) DNA-binding molecules (unfused aromatic Keywords: amplifier, anticancer drug, dna damage, apoptosis, dna-binding compound, (PDF) Research Project on anticancer drug-DNA interactions Molecular Biology of Human Cancers: An Advanced Student's Textbook. Article. Jan 2005. Small DNA-interacting molecules share the ability of certain proteins to The present paper describes the molecular basis of DNA destabilization, the However, some covalent DNA-binding anticancer drugs can also This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that